Preimplantation Genetic Diagnosis-Baby's Beginning

My experiences of concieving our first child using preimplantation genetic diagnosis

Friday, June 12, 2009

Plan #5 and an exciting new option - "Mini PGD"

My goodness... are we really on Plan #5 now?? Well, this one I think will be a lot less painful. I recently found out about a new option, called "Minimal Stimulation IVF" or "MS IVF" (with PGD of course). Basically, instead of having to give yourself injections, pumping your body full of drugs, hyper-stimulating your ovaries and forcing them to produce a ton of eggs, many of which are of very poor quality, you get a more natural approach. Instead of injections, you get oral medications (it looks like usually Clomid is the main one used), and a nasal spray. (For those not familiar with Clomid, it's a very common fertility drug that's fairly gentle compared with the other more potent drugs and dosages used in conventional IVF). Instead of forcing your ovaries to produce 10-20 eggs, you just gently increase production to 3-5 eggs. No more painful, enlarged, tender ovaries! In fact, instead of the "twilight" anesthesia that puts you completely out that is necessary during a conventional IVF egg retrieval, they usually just give you a local anesthesia or just an oral pain med, since your ovaries aren't so large and tender, it's just not necessary.

This sounds like such a healthier option to me! Their success rates are actually the same as conventional IVF as well, because although you get less eggs, they're of higher quality, so you have less eggs with random chromosome problems and more that will grow into healthy pregnancies. Egg quality was what killed us on our previous PGD. Even though we had half without the genetic disorder, they either had a random other problem, or just didn't grow for no reason. And not to mention, there's usually no injections! They say some women require a few injections depending on your specific situation, but they are always much less than with conventional IVF. Sounds awesome to me! It's freaky having to give yourself shots.

The #1 clinic in the U.S. that does this is the New Hope Fertility Center in New York. For international readers, I believe Japan is currently the leader in this new method. Check out their website, they've got a lot of good information on there. The one negative I've found so far, is that they send out most of their PGDs. They only do PGDs in their center for gender selection. The rest are sent to another clinic for analysis. It makes me nervous thinking of our embryos being sent back and forth, that's why we travelled to RGI in Chicago before, to avoid our babies getting shipped. However, I think the safety and health benefits of their method is more important than avoiding shipping, so we'll just have to go with that. It is a very common thing, I know. Just makes me nervous.

I called them up today for the first time, and their setup is very easy. We don't have to do anything until we're ready to do the pretests and exams, which is certainly a nice change from the never ending paper pile we went through at RGI. RGI will still do our PGD portion of the procedure, since they are really one of the few that has experience with our genetic disorder and they already have our probe done. They don't accept our insurance, so I'm not sure if they will help us file an insurance claim or if we'll need to do that on our own, which will be a bit of a headache. However the cost of this is less as well - it looks like it will cost roughly about $10,000, according to the fees on their website, as opposed to the about $25,000 at RGI.

I'm going to take a long 6 months to recover this time. One for each month of pregnancy, plus one since I know now that a termination is harder on the body than a miscarriage, plus another one just for my husband, who is really worried about my poor body after all these procedures and is also just a bit stressed out and needs a break. It will work out well since we can do the pretests and exams before the holidays, then do the PGD cycle in January.


Blogger Greg and Kim said...

I came across your blog a year or so ago and can't tell you how helpful it has been. I am 27 and also have a very mild case of IP. I just got my test results back from Baylor and the deletion was fortunately detected, so we are in the process of deciding on a facility for IVF. Your blog has been immensely helpful to me. We are looking at the Reproductive Genetics Institute you used in Chicago and also the Genetics and IVF Institute in Virginia (I'm in NC). Pros and cons to both. I'm planning to talk to genetic counselors at both tomorrow so we can make a decision (hubby deploys at the end of the month). Dana is my contact as well. :) I just wanted to say thank for documenting your experiences. If you'd like to stay in touch, my personal email is I check your blog frequently and wish you the best of luck!

Wednesday, July 08, 2009 2:02:00 p.m.  
Anonymous Anonymous said...

God bless you - you have been through so much. I am praying for you and wish you happiness and peace. Thank you for sharing your story.

Thursday, August 27, 2009 6:16:00 p.m.  

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